Heat Shock Proteins (HSP) in Cellular Communication and Signaling
نویسندگان
چکیده
The book Heat Shock Proteins (HSP) in Cellular Communication and Signaling Volume 26 provides the most comprehensive highlight insight of expression, function therapeutic activity HSP signaling pathways. Using an integrative approach to understanding various HSP-mediated pathways response a variety stressors including hyperthermia, or metabolic changes produced by physical exercise psychological stress, regulates stability, activation, degradation diverse array proteins associated with growth, proliferation, survival via regulation protein stability protein-degradation modulating transcription factors/signal transduction networks. It facilitates cells during stress exhibits pronounced anti-apoptotic stabilization effect. performs functions transportation refolding from cytoplasm into mitochondrial matrix many diseases.
منابع مشابه
HDAC Inhibitors and Heat Shock Proteins (Hsps)
Epigenetic alterations, including DNA acetylation, hypermethylation and hypomethylation, and the associated transcriptional changes of the affected genes are central to the evolution and progression of various human cancers, including pancreatic cancer. Cancer-associated epigenetic alterations are attractive therapeutic targets because such epigenetic alterations, unlike genetic changes, are po...
متن کاملHeat shock proteins in thermotolerance and other cellular processes.
Heat shock proteins appear to be causatively involved in the acquisition of thermotolerance in prokaryotes but not in eukaryotes. Further, the enhanced synthesis of hsps may be necessary for some cellular responses to stress but not others. In prokaryotic cells the development of thermotolerance, as measured by cell survival, is dependent upon protein synthesis. However, in eukaryotes, enhanced...
متن کاملHeat shock and the heat shock proteins.
As all biologists appreciate, there is constant interaction between life and the environment, and temperature plays a critical role. It establishes distribution limits, it affects rates of function as well as the survival of organisms. Notoriously sensitive to temperature is plant growth. Critical steps in plant life such as germination, flowering and breaking of dormancy can be manipulated by ...
متن کاملSpecies-specific collaboration of heat shock proteins (Hsp) 70 and 100 in thermotolerance and protein disaggregation.
Yeast Hsp104 and its bacterial homolog, ClpB, are Clp/Hsp100 molecular chaperones and AAA+ ATPases. Hsp104 and ClpB collaborate with the Hsp70 and DnaK chaperone systems, respectively, to retrieve and reactivate stress-denatured proteins from aggregates. The action of Hsp104 and ClpB in promoting cell survival following heat stress is species-specific: Hsp104 cannot function in bacteria and Clp...
متن کاملHeat shock proteins and the cellular response to osmotic stress.
In antidiuresis, the intrarenal distribution of HSP25/27, alphaB-crystallin, HSP72, OSP94 and HSP110 corresponds to the osmotic gradient between cortex and papilla: low amounts in the cortex and high values in the inner medulla and papilla. In addition, medullary HSP72 levels change appropriately with the diuretic state. Studies on MDCK cells suggest that, in the renal medulla in vivo, stressor...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Heat shock proteins
سال: 2022
ISSN: ['1877-1254', '1877-1246']
DOI: https://doi.org/10.25259/hsp-26